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Immunopathology of experimental schistosome ( S. Mansoni ) egg granulomas in mice—possible defence mechanisms mediated by local immune complexes
Author(s) -
de Brito T.,
HoshinoShimizu Sumie,
da Silva L. C.,
Kanamura Hermīnia,
Costa Cecīlia M.,
Pinto P. S.
Publication year - 1983
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711400104
Subject(s) - granuloma , immune system , antigen , antibody , schistosoma mansoni , immunology , biology , delayed hypersensitivity , granulomatous inflammation , inflammation , humoral immunity , schistosomiasis , pathology , helminths , medicine
Abstract A ten month experimental S. Mansoni infection was followed in mice by studying schistosome egg granulomatous inflammation, antigen and immunoglobulins deposits in the granulomata and the circulating antibodies. During the experimental infection it was demonstrated that while the granulomatous reaction matures there is a progressive restriction of the antigens to the miracidia. Furthermore, immunoglobulins, particularly IgG and C 3 deposits were demonstrated in the granulomata. Our data support the concept that schistosome egg granuloma is a hypersensitivity high turnover granuloma that is particularly efficient in walling off the antigen. Whereas the granuloma is built up largely by a cell mediated immune reaction, antibody deposits are also found, probably functioning as a local humoral antibody barrier which allows a slow and progressive neutralisation of the antigens. Viewed as a whole, experimental schistosome egg granuloma might be considered as a mixed, chiefly cell but also humoral antibody mediated immune reaction.