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The histopathology of tissues in “resistant” and “susceptible” strains of mice infected with a moderate dose of Mycobacterium lepraemurium
Author(s) -
Adu Hannah O.,
Turk J. L.,
Curtis Jill
Publication year - 1983
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711390305
Subject(s) - infiltration (hvac) , histopathology , microbiology and biotechnology , biology , mycobacterium , bacilli , epithelioid cell , cellular infiltration , lymphocytic infiltration , pathology , bacteria , inflammation , immunology , medicine , immunohistochemistry , physics , genetics , thermodynamics
A systematic study by light and electron microscopy of tissues from BALB/c and C57BL/6 mice infected subcutaneously with 107 Mycobacterium lepraemurium organisms was carried out at various times throughout the infection. The relatively resistant C57BL/6 mice had an earlier inflammatory response at the site of the infection than did the susceptible BALB/c mice. The infiltration in the former strain contained fibroblast‐like cells and epithelioid cells early on in the infection. Few lymphocytes were observed in both strains throughout the infection. The spread of acid‐fast bacilli was slower in the resistant strain (C57BL/6). The findings indicated that the rate of cellular infiltration at the infection site and the nature of the cells in the infiltration may determine the outcome of this infection.