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A new reproducible experimental model of analgesic nephropathy
Author(s) -
Henry M. A.,
Sweet R. S.,
Tange J. D.
Publication year - 1983
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711390103
Subject(s) - phenacetin , nephrotoxicity , analgesic , renal papillary necrosis , aspirin , medicine , necrosis , nephropathy , pharmacology , acetaminophen , kidney , endocrinology , diabetes mellitus
The uninephrectomised homozygous Gunn rat is more sensitive than other experimental animals to the nephrotoxic effects of analgesics. Phenacetin derivatives produce severe necrosis of proximal convoluted tubules and aspirin and phenazone renal papillary necrosis. The observations suggest that the components of compound analgesic preparations have separate and complementary nephrotoxic effects, and this is a possible factor contributing to the association of analgesic nephropathy with abuse of such preparations.