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An ultrastructural study of the origin and function of basophilic degeneration in human cardiac muscle—cardiac colloid. Type 1
Author(s) -
Gregory M. A.,
Olmesdahl P. J.,
Whitton I. D.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711380405
Subject(s) - endoplasmic reticulum , lipofuscin , colloid cyst , organelle , vacuole , basophilic , ultrastructure , cardiac muscle , ventricle , pathology , cytoplasm , colloid , chemistry , lysosome , electron microscope , vesicle , anatomy , biology , microbiology and biotechnology , membrane , biochemistry , medicine , third ventricle , enzyme , physics , optics
Abstract The myofibres in biopsies obtained from the left ventricle during cardiopulmonary bypass, in patients undergoing surgery for mitral and aortic valve replacement and the correction of atrial septal defect, contained inclusions thought to be type 1 cardiac colloid. Electron microscopy showed this material to be synthesised by and contained within a grossly dilated rough endoplasmic reticulum. The presence of membrane‐bound aggregates of non‐fibrillar sarcoplasmic organelles within colloid deposits, together with osmiophilic inclusions thought to be related to lipofuscin, both within and moving from this structure, suggest that type 1 cardiac colloid is an autophagic vacuole designed to degrade ageing or redundant sarcoplasmic organelles.