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Phagocytosis of the a band following Z line, and I band loss. Its significance in skeletal muscle breakdown
Author(s) -
Cullen M. J.,
Fulthorpe J. J.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711380204
Subject(s) - phagocytosis , line (geometry) , skeletal muscle , medicine , biology , microbiology and biotechnology , anatomy , mathematics , geometry
Abstract A band phagocytosis, following Z line and I band loss. is described in polymyositis, in epsilon amino caproic acid induced myopathy and in an experimental myositis of guinea pigs. It is far less prominent in Duchenne muscular dystrophy. This form of necrosis is always associated with lesions in the plasma membrane. It is argued that the ensuing ionic equilibration with the extracellular fluid allows activation of a calcium activated proteinase (CAP) which digests the Z line. Breakdown of the myofibrils into individual A bands promotes rapid phagocytosis of the myofibre contents and facilitates regeneration of the muscle.