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Ultrastructural localisation of fibronectin in mouse kidney
Author(s) -
Dixon A. Jane,
Burns J.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711380104
Subject(s) - fibronectin , ultrastructure , immunoperoxidase , basement membrane , cytochemistry , pathology , epithelium , biology , matrix (chemical analysis) , microbiology and biotechnology , chemistry , anatomy , extracellular matrix , medicine , immunology , antibody , chromatography , monoclonal antibody
The ultrastructural localisation of fibronectin in mouse kidney was investigated by indirect immunoperoxidase cytochemistry. In glomeruli, fibronectin was found predominantly in matrix between endothelial and mesangial cells. Smaller quantities were demonstrable in peripheral capillary walls both subendothelially and around visceral epithelial cell foot processes. It was present between parietal epithelial cells and Bowman's capsule and at the base of tubular epithelial cells outlining the inner aspect of tubular basement membranes.