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Factors influencing the severity and progress of ethylenimine‐induced papillary necrosis
Author(s) -
Davies D. J.,
Tange J. D.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711370405
Subject(s) - renal papilla , renal papillary necrosis , major duodenal papilla , necrosis , renal medulla , medulla , lesion , acute tubular necrosis , urinary system , endocrinology , medicine , diuresis , kidney , pathology , urology , chemistry
The severity of the renal papillary necrosis produced in rats by ethylenimine is dependent both on dose and urinary concentration within the medulla. When this is reduced by diuresis, the severity of the lesion is effectively reduced. Increasing urinary concentration has a reverse effect, but of less magnitude. When the concentrating power of the renal medulla is impaired by a single dose of ethylenimine, insufficient to cause necrosis of the whole papilla, further doses of ethylenimine do not cause progressive damage to the papilla.