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The effects of various anti‐calcific, anti‐rheumatic and anti‐inflammatory drugs on local (simple) calcergy induced by lead acetate in the mouse
Author(s) -
McClure J.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711370308
Subject(s) - lead acetate , prednisolone , calcification , resorption , calcitonin , subcutaneous injection , chemistry , anti inflammatory , pharmacology , medicine , endocrinology , toxicity
The diphosphonate compound ethane‐hydroxy‐1, 1‐diphosphonate (EHDP) is an effective inhibitor of the calcification reaction induced by the subcutaneous injection of lead acetate in the mouse. Dichloromethylene. diphosphonate (CI 2 MDP) has no such effect and prednisolone and sodium aurothiomalate are also ineffective in inhibiting the reaction. The rate of resorption of the calcified plaque is decreased by CI 2 MDP when this is administered on an extended basis. This effect disappears after prolonged treatment so that EHDP, calcitonin and CI 2 MDP have no effect after 7 weeks of daily treatment.