The effects of various anti‐calcific, anti‐rheumatic and anti‐inflammatory drugs on local (simple) calcergy induced by lead acetate in the mouse | Zendy

McClure J. | Zendy

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The effects of various anti‐calcific, anti‐rheumatic and anti‐inflammatory drugs on local (simple) calcergy induced by lead acetate in the mouse

Author(s) -

McClure J.

Publication year - 1982

Publication title -

the journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.964

H-Index - 184

eISSN - 1096-9896

pISSN - 0022-3417

DOI - 10.1002/path.1711370308

Subject(s) - lead acetate , prednisolone , calcification , resorption , calcitonin , subcutaneous injection , chemistry , anti inflammatory , pharmacology , medicine , endocrinology , toxicity

The diphosphonate compound ethane‐hydroxy‐1, 1‐diphosphonate (EHDP) is an effective inhibitor of the calcification reaction induced by the subcutaneous injection of lead acetate in the mouse. Dichloromethylene. diphosphonate (CI 2 MDP) has no such effect and prednisolone and sodium aurothiomalate are also ineffective in inhibiting the reaction. The rate of resorption of the calcified plaque is decreased by CI 2 MDP when this is administered on an extended basis. This effect disappears after prolonged treatment so that EHDP, calcitonin and CI 2 MDP have no effect after 7 weeks of daily treatment.

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