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Direct evidence that inflammatory multinucleate giant cells form by fusion
Author(s) -
Murch A. R.,
Grounds Miranda D.,
Marshall C. A.,
Papadimitriou J. M.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711370302
Subject(s) - multinucleate , cell fusion , giant cell , cytoplasm , strain (injury) , biology , heterokaryon , fusion , macrophage , isomerase , microbiology and biotechnology , cell culture , genetics , enzyme , biochemistry , in vitro , gene , anatomy , philosophy , linguistics , mutant
Multinucleate giant cells (MGC) are believed to be formed by fusion of macrophages. In a chimaeric mouse composed of two histoincompatible strains each homozygous for one of the two isoenzymic forms of glucose‐6‐phosphate isomerase it was found that hybrid enzyme was produced in MGC‐rich leucocytic exudates. This hybrid can only occur if nuclei of the two different strains reside within a common syncytial cytoplasm, demonstrating unequivocally that macrophage fusion occurred between cells of the two strains. Since the two strains were histoincompatible it appears that no strain specific recognition is necessary for fusion to occur.