Premium
Enolase isoenzyme distribution in the human brain and its tumours
Author(s) -
Royds Janice A.,
Parsons M. A.,
Taylor C. B.,
Timperley W. R.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711370105
Subject(s) - enolase , isozyme , human brain , pathology , distribution (mathematics) , biology , medicine , biochemistry , immunohistochemistry , enzyme , neuroscience , mathematics , mathematical analysis
Using the immunoperoxidase PAP method we have studied the cellular distribution of α, β and γ enolase subtypes in normal human adult brain and in human brain neoplasms. γ enolase is found only in viable neurones throughout the brain. α enolase is demonstrable in astrocytes, ependymal cells, capillary endothelial cells, Schwann cells and arachnoidal endothelial cells but oligodendrocytes appear to have low levels of this isoenzyme. β enolase is not demonstrable in normal brain tissues. Of the primary cerebral neoplasm studied only medullo‐blastomas and neuroblastomas did not contain demonstrable enolase. Astrocytomas, ependymomas, oligodendrocytomas, meningiomas and acoustic neuromas all contained varying quantities of α enolase. No cerebral tumours contained β or γ enolase. Tumour and adjacent brain tissue with histological evidence of ischaemia and necrosis showed loss of cellular enolase.