Premium
Ultrastructural changes in skeletal muscles in dengue virus‐infected mice
Author(s) -
Nath Pramod,
Agrawal Devendra K.,
Mehrotra R. M. L.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711360405
Subject(s) - endoplasmic reticulum , myofibril , glycogen , ultrastructure , cytoplasm , dengue virus , sarcoplasm , virus , virology , sarcolemma , inoculation , mitochondrion , biology , dengue fever , skeletal muscle , anatomy , pathology , chemistry , microbiology and biotechnology , endocrinology , medicine , immunology
Abstract Dengue type 2 virus was inoculated intracerebrally in 20 adult swiss albino mice. Thigh muscles were removed after 24 h 3, 5 and 7 days after virus inoculation. Electron microscopic studies of the striated muscles show destruction of myofibrils, rarification of the sarcoplasmic reticulum network and changes in the mitochondria. Aggregates of electron‐dense material as well as glycogen particles were also seen in the cytoplasm.