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Renal malakoplakia. Experimental production and evidence of a link with interstitial megalocytic nephritis
Author(s) -
Garrett I. R.,
McClure J.
Publication year - 1982
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711360205
Subject(s) - malakoplakia , nephritis , interstitial nephritis , antigen , cytoplasm , pathology , chemistry , kidney , immunology , medicine , biochemistry
The intrarenal injection of Boivin antigen is followed by the development of true malakoplakic lesions as characterised by the accumulation of macrophages containing MG bodies. Similarly the injection of diluted antigen is followed by the accumulation of macrophages with a granular PAS‐positive cytoplasm but lacking MG bodies. These experimental models are compared with typical human renal malakoplakia and that entity known as megalocytic interstitial nephritis.