Premium
A survey of pathological changes associated with long‐term high tar tobacco smoke exposure in a murine model
Author(s) -
Keast D.,
Ayre D. J.,
Papadimitriou J. M.
Publication year - 1981
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711350402
Subject(s) - tar (computing) , pathological , smoke , medicine , tobacco smoke , pathology , interstitial pneumonia , lung , life span , physiology , toxicology , biology , environmental health , chemistry , organic chemistry , computer science , programming language , gerontology
Balb/c mice were exposed to the fresh smoke of a daily equivalent of thirty high tar filtered cigarettes for periods of up to 95 weeks. Detailed surveys of the gross and histopathological data are presented which indicates that there is the induction or production of significant numbers of malignant tumours of several types in the animals exposed to tobacco smoke. There are also significant histopathological changes which consist mainly of interstitial pneumonia and focal low grade emphysema. These features contribute significantly to the reduction in life span of the test animals in which the main causes of death are malignancies and inflammatory diseases of the lungs.