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A transplantable human malignant Schwannoma
Author(s) -
Rao M. Sambasiva,
Chaudhuri Bina,
Scarpelli D. G.
Publication year - 1981
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711350302
Subject(s) - schwannoma , embryonic stem cell , transplantation , pathology , biology , metastasis , medicine , cancer , gene , biochemistry , genetics
A human malignant Schwannoma was serially transplanted through three generations in nude mice. The tumours grew readily and the take‐up rate was 100 per cent. No metastasis was observed in nude mice. Morphological features of the original tumour were strictly maintained through all the transplant generations. The tumour cells of the original and of the transplants showed features of primitive Schwann cells of embryonic nerve trunks.