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Differentiation of human breast carcinomas: An immunohistological study of appropriate and inappropriate protein production
Author(s) -
Walker Rosemary A.
Publication year - 1981
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711350106
Subject(s) - immunoperoxidase , syncytiotrophoblast , glycoprotein , immunohistochemistry , staining , antibody , secretory protein , placenta , antigen , biology , pathology , immunocytochemistry , pregnancy , immunology , fetus , monoclonal antibody , microbiology and biotechnology , medicine , endocrinology , secretion , genetics
Secretory piece of immunoglobulin A, a product of normal breast tissue, and beta 1 pregnancy‐specific glycoprotein, a product of syncytiotrophoblast of placenta, have been demonstrated in breast carcinomas by an indirect immunoperoxidase method. A close relationship has been found between the site of staining within cells and tumour structure for both secretory piece, the appropriate protein, and beta 1 pregnancy‐specific glycoprotein, the inappropriate protein. The reaction was at the periphery of cells in areas of tubular differentiation and was diffusely intracytoplasmic in solid groups of tumour cells. The poorly differentiated carcinomas have a low incidence of detection for both antigens but the tumours showing good histological differentiation appear to be functionally heterogeneous with some being negative for both proteins, some staining for the appropriate secretory piece of immunoglobulin A and the inappropriate beta 1 pregnancy‐specific glycoprotein and only one out of 12 producing the appropriate protein alone.