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Hypersecretion of mucus glycoprotein by the gallbladder epithelium in experimental cholelithiasis
Author(s) -
Lee S. P.
Publication year - 1981
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711340304
Subject(s) - mucin , mucus , gallbladder , epithelium , glycoprotein , cholic acid , biology , chemistry , pathology , cholesterol , medicine , biochemistry , ecology
In three models of cholelithiasis (dihydrocholesterol‐fed rabbits, cholesterol‐cholic acid‐fed mice, and Lincomycin‐treated guinea pigs), the quantity and chemical composition of gallbladder epithelial mucin have been studied using (1) a spectrum of histochemical glycoprotein stains, and (2) biochemical extraction, purification and analysis of the carbohydrate components of epithelial mucin. Despite the diverse mechanism of stone induction and difference in stone composition, a common pattern of response by the epithelial mucin was observed in all three models. There was a quantitative increase in epithelial mucus production at a time before stones were formed and this increase persisted till stones were formed. There was no difference, qualitatively, between mucus produced by normal and stone‐forming gallbladders.