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Histochemical studies of hepatocellular carcinomas in the rat induced by aflatoxin
Author(s) -
Butler W. H.,
Hempsall Valerie
Publication year - 1981
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711340206
Subject(s) - aflatoxin , pathology , hepatocellular carcinoma , biology , adenoma , atpase , glycogen , carcinoma , incidence (geometry) , enzyme , medicine , cancer research , biochemistry , physics , food science , optics
A histochemical study has been done on a group of 18 hepatocarcinomas induced by aflatoxin. One hundred per cent. incidence of hepatocarcinomas is induced by feeding 5 p.p.m. aflatoxin for 6 weeks. The carcinomas were trabecular hepatocarcinomas with a mixed adenomatous pattern and showed considerable variation in histochemical reactions throughout the lesions. There was a patohy distribution of glycogen and glucose‐6‐phosphatase and the membrane ATPase was present along much of the canalicular border of the cells but with an abnormal and tortuous pattern. Aniline hydroxylase was present in varying amounts in both trabecular and adenomatous carcinomas. It is concluded that the histological variants of hepatocarcinoma are all derived from hepatocytes, but no unique changes were observed related to the progress involved in malignant neoplasia. The observations form a basis for comparison with early lesions seen prior to the recognition of carcinoma.