Premium
Mechanism of the induction of angiogenesis by human neoplastic lymphoid tissue: Studies employing bovine aortic endothelial cells in vitro
Author(s) -
Mostafa L. K.,
Jones D. B.,
Wright D. H.
Publication year - 1980
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711320303
Subject(s) - wright , medicine , pathology , library science , computer science , history , art history
Extracts of human neoplastic tissue (three Hodgkin's lymphomas; three gliomas and one liposarcoma) previously shown to induce angiogenesis in vivo did not stimulate the proliferation of bovine aortic endothelial cell monolayers when tested in vitro. Proliferation was induced by coculture of endothelial cells with human or animal macrophages or with supernatants derived from these cells. However, angiogenic extracts were chemotactic both for guinea pig peritoneal macrophages and human mononuclear cells in vitro. These results imply that tumour extracts act indirectly to induce angiogenesis in vivo via their effect on host macrophages.