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Tumorgenicity of Herpesvirus hominis type 2‐transformed cells (line 333‐8‐9) in adult hamsters
Author(s) -
Shortland J. R.,
Mousawy K. M.,
Rees R. C.,
Potter C. W.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711290403
Subject(s) - hamster , fibrosarcoma , virus , pathology , biology , syrian hamsters , virology , medicine , microbiology and biotechnology
Inoculation of adult hamsters with greater than 1.5 X 10(2) Herpesvirus type 2 (HSV-2) transformed hamster embryo fibroblasts induced rapidly growing tumours at the site of inoculation, in more than 50 per cent of animals. The tumours were examined by light and electron microscopy, and were histologically anaplastic fibrosarcomas. Lung metastases were frequently found in tumour-bearing animals; these were usually only seen microscopically, and were cytologically similar to the primary tumours. The nature of tumour development showed similarities with naturally occurring tumours of man, and HSV-2 tumour is probably a better model of human cancer than other virus-induced tumours studied in the past.