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Mediation by serotonin of gold thioglucose‐induced necrosis of the ventromedial hypothalamus
Author(s) -
Debons A. F.,
Krimsky I.,
From Annette,
Siclari E.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711290206
Subject(s) - medicine , administration (probate law) , gerontology , political science , law
Agents that lower serotonin levels or inhibit serotonin action prevent GTG-indurea and that such damage leads to abnormally increased capillary permeability. Since the VMH is rich in serotonin and since serotonin is a potent oedema-producing agent mice, these findings indicate that the production of necrosis by GTG is mediated by release of serotonin from the damaged pericapillary processes.