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Action of gold thioglucose on pericapillary structures in the ventromedial hypothalamus
Author(s) -
Debons A. F.,
Krimsky I.,
From Annette,
Siclari E.,
Maayan M. L.,
Fani K.,
Jimenez F. A.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711290205
Subject(s) - hypothalamus , action (physics) , medicine , physics , quantum mechanics
The administration of GTG to mice leads to death of all structures in a circumscribed area of the VMH as a result of loss of blood circulation. The loss of circulation is due to damage by GTG of neural processes adjacent to some of the capillaries in this area; damage to these processes leads to abnormal capillary permeability. Pericapillary damage occurs under conditions where capillary damage and consequent necrosis are prevented. Abnormal capillary permeability appears to follow release of a vasoactive substance from the damaged neural processes. Damage to the pericapillary neural processes by GTG is insulin-dependent and is counteracted by glucocorticoids.