Premium
Experimental murine amyloidosis: Experience with Candida albicans as an amyloidogenic agent and liver biopsy as a diagnostic tool
Author(s) -
Savage Ann,
Tribe C. R.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711270407
Subject(s) - candida albicans , amyloidosis , biopsy , pathology , medicine , chemistry , microbiology and biotechnology , biology
We describe a method of inducing experimental amyloidosis in mice using injections of Candida albicans. Both viable and non-viable Candida produced amyloid and we compare the results with each method. Diagnosis was by liver biopsy, a technique of value in assessing the natural history of the disease. Once the amyloid had been induced, the disease always progressed until the animals died of generalised amyloidosis. This experimental model should, therefore, be suitable to use in assessing the treatment of amyloidosis.