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In‐vitro modification of membrane‐ receptors on cells of the mononuclear phagocyte system
Author(s) -
Ridley Marian,
Turk J. L.,
BadenochJones P.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711270403
Subject(s) - receptor , mononuclear phagocyte system , zymosan , in vitro , chemistry , macrophage , cell surface receptor , phagocyte , immunology , peripheral blood mononuclear cell , phagocytosis , pathology , biology , medicine , biochemistry
EA and EAC receptors have been studied on non-elicited and paraffin-induced macrophages, under a variety of culture conditions in vitro, for up to 7 days. A large decrease in the number of macrophages showing EAC receptors was found after treatment of the cells with BCG, but not "inert" particles such as latex and zymosan. This was reversible by 7 days. In the presence of a toxic material, Al(OH)3, both EA and EAC receptors were partially lost. The results obtained have been related to previous results obtained with cryostat sections of human leprosy skin lesions.