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An experimental assessment of macroscopic enzyme techniques for the autopsy demonstration of myocardial infarction
Author(s) -
Anderson K. R.,
Popple A.,
Parker D. J.,
Sayer R.,
Trickey R. J.,
Davies M. J.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711270207
Subject(s) - myocardial infarction , autopsy , medicine , infarction , cardiology , ligation , cardiac enzymes , radiology
Experimental cardiac infarction produced in dogs by coronary artery ligation has been used to investigate the value of macroscopic histochemical enzyme loss in the diagnosis of myocardial infarction at post-mortem. Creative phosphokinase and non-specific dehydrogenase methods gave the best results but became positive only 5-6 hr after infarction. It is concluded that the method is of limited value in autopsy practice.