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Phagocytosis and trypsin‐resistant glass adhesion by osteoclasts in culture
Author(s) -
Chambers T. J.
Publication year - 1979
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711270202
Subject(s) - phagocytosis , trypsin , adhesion , osteoclast , in vitro , mononuclear phagocyte system , cell adhesion , peripheral blood mononuclear cell , phagocyte , chemistry , microbiology and biotechnology , biology , immunology , biochemistry , enzyme , organic chemistry
Osteoclasts were cultured in vitro and tested for the functions normally associated with cells of the mononuclear phagocyte system. They were found to ingest glutaraldehyde-fixed red cells and latex, but not opsonised or complement-coated sheep red cells. Osteoclasts are glass-adherent and resist removal by trypsin. The implications of these findings for the identity of the osteoclast precursor cell and its mechanism of fusion are discussed.