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Endocytosis and formation of macrophage polykarya: An ultrastructural study
Author(s) -
Papadimitriou J. M.
Publication year - 1978
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711260405
Subject(s) - ultrastructure , endocytosis , macrophage , microbiology and biotechnology , biology , pathology , medicine , cell , biochemistry , in vitro
Mononuclear phagocytes in foreign body granulomas become entrapped by the lamellipodia or enter the intracytoplasmic membranous labyrinth of macrophage polykarya. Evidence of membrane fusion was found in such instances and it is suggested that the internalisation of the mononuclear phagocyte is allied to the motility of the syncytium. This concept is also supported by the reports of other authors who emphasise the role of endocytosis in the formation of macrophage polykarya. The net effect of such a mechanism is growth of the syncytium.