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Histological and ultrastructural changes in experimentally produced post‐vaccinial lymphadenitis in rabbits
Author(s) -
Mehrotra Raj
Publication year - 1978
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711260106
Subject(s) - pathology , medicine
Light and Electron microscopic alterations in lymph nodes after intradermal vaccinia virus inoculation are described. In the early stages the lymph nodes show a diffuse lymphoreticular proliferation associated with the appearance of peculiar large cells called reticulolymphoblasts. This appearance can be mistaken for malignant lymphoma. Later on, these changes are replaced by markedly hypertrophied lymphoid follicles which persist for long periods. These alterations can be mistaken for follicular lymphoma. Evidence is presented that reticulolymphoblasts are derived from transformed lymphocytes.