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Immunoglobulin in Reed‐Sternberg and Hodgkin cells
Author(s) -
Curran R. C.,
Jones E. L.
Publication year - 1978
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711260105
Subject(s) - curran , medical school , citation , reed–sternberg cell , medicine , library science , computer science , pathology , medical education , biology , lymphoma , botany , hodgkin lymphoma
In eight cases of Hodgkin's disease of various types, Ig was found within approximately one-third of the RS and HD cells. The Ig within each RS and HD cell consisted of gamma heavy chains and both k and lambda light chains. The most probable origin of the Ig would appear to be uptake of IgG-containing immune complexes. The presence of both types of light chain in individual RS and HD cells is inconsistent with an origin of these types of cell from B lymphocytes.