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H 2 ‐receptors and traumatic oedema
Author(s) -
Little R. A.,
Savic J.,
Stoner H. B.
Publication year - 1978
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711250405
Subject(s) - unit (ring theory) , citation , medical school , medicine , library science , psychology , medical education , mathematics education , computer science
The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat. No inhibition of oedema formation was found except when large doses of cimetidine were given before scalding. This effect was attributed to the fall in body temperature. Our results do not support the view that H2-receptors are concerned in the vascular response to injury.