Some effects of a thallium salt on the proliferation of hair follicle cells | Zendy

Cavanagh J. B. | Zendy; Gregson M. | Zendy

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Some effects of a thallium salt on the proliferation of hair follicle cells

Author(s) -

Cavanagh J. B.,

Gregson M.

Publication year - 1978

Publication title -

the journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.964

H-Index - 184

eISSN - 1096-9896

pISSN - 0022-3417

DOI - 10.1002/path.1711250403

Subject(s) - hair follicle , thallium , salt (chemistry) , follicle , chemistry , microbiology and biotechnology , medicine , endocrinology , biology , inorganic chemistry

Thallium sulphate has been given to young rats at 4 and 7 days of age and the mitotic activity of the hair follicles has been assessed quantitatively. It has been found that there is a marked decline in mitotic rate over 48 hr in the thallium-treated animals, which is followed by variable amounts of cell death in the matrix zone. No specific mitotic lesion was found or change in cell cycle indices. A failure of energy metabolism is suggested as a possible cause of the inhibition of hair follicle mitosis by thallium.

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