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Some effects of a thallium salt on the proliferation of hair follicle cells
Author(s) -
Cavanagh J. B.,
Gregson M.
Publication year - 1978
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711250403
Subject(s) - hair follicle , thallium , salt (chemistry) , follicle , chemistry , microbiology and biotechnology , medicine , endocrinology , biology , inorganic chemistry
Thallium sulphate has been given to young rats at 4 and 7 days of age and the mitotic activity of the hair follicles has been assessed quantitatively. It has been found that there is a marked decline in mitotic rate over 48 hr in the thallium-treated animals, which is followed by variable amounts of cell death in the matrix zone. No specific mitotic lesion was found or change in cell cycle indices. A failure of energy metabolism is suggested as a possible cause of the inhibition of hair follicle mitosis by thallium.