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Ultrastructure of intramuscular haematomas and electron‐probe X‐ray analysis of extracellular and intracellular iron deposits
Author(s) -
Lalonde J.M. A.,
Ghadially F. N.,
Massey K. L.
Publication year - 1978
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711250104
Subject(s) - university hospital , general hospital , library science , medicine , general surgery , surgery , computer science
Haematomas were produced in rabbits by intramuscular injections of autologous blood. Clotting and marked lysis of erythrocytes was noted in these haematomas but there was no evidence of fragmentation of erythrocytes, prior to, during, or after ingestion by macrophages as has been reported in other sites such as spleen, peritoneal cavity or joint cavity. The phagocytosis of intact erythrocytes, lysed erythrocytes and haemoglobin led to the formation of three main types of lysosomal bodies, (1) myelinosomes, (2) siderosomes and (3) myelinosidersomes. Electron-probe X-ray analysis of siderosomes has yielded further data supporting the idea that haemosiderin is essentially an inorganic iron compound; presumably a hydrated ferric oxide. An unusual and hitherto unreported finding was the occurrence of electron-dense granules in the connective tissue matrix in two animals. The granules were shown to contain iron, calcium, potassium and phosphorus. It is thought they might represent an attempt at pathological calcification in damaged tissue.