Premium
Cyclic amp and the mechanism of leucocyte lysosomal enzyme release during an immediate hypersensitivity reaction in vivo
Author(s) -
Deporter D. A.
Publication year - 1977
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711230302
Subject(s) - in vivo , chemistry , enzyme , mechanism (biology) , delayed hypersensitivity , pharmacology , medicine , biochemistry , immunology , biology , immune system , philosophy , epistemology , microbiology and biotechnology
The pleural cavity of rats was used to study the effect of altering leucocyte cyclic AMP content on the release of B-glucuronidase activity during an immediate hypersensitivity reaction. The effect on intravenous colchicine was also studied. Despite an increase of 135 to 235% in leucocyte cyclic AMP content no decrease in B-glucuronidase release was observed. Similarly, colchicine had no effect on enzyme release. It was concluded that the cyclic nucleotides and leucocyte microtubules may have no significant role to play in the release of lysosomal enzymes during acute inflammation in vivo.