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Characteristics of mononuclear cell populations in chronically inflamed synovial membranes
Author(s) -
Meijer C. J. L. M.,
van de Putte L. B. A.,
Eulderink F.,
Kleinjan R.,
Lafeber G.,
Bots G. Th. A. M.
Publication year - 1977
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711210102
Subject(s) - peripheral blood mononuclear cell , membrane , cell , synovial membrane , mononuclear cell infiltration , chemistry , pathology , biology , medicine , immunology , inflammation , biochemistry , in vitro
Mononuclear cells infiltrating synovial membranes in chronic synovitis were characterised both in situ and in cell suspensions by surface markers and histochemical techniques. T-lymphocytes were the predominant infiltrating cell in rheumatoid arthritis as well as in other forms of chronic arthritis, including ankylosing spondylitis and arthritis associated with Crohn's disease. B-lymphocytes were found exclusively in rheumatoid synovial membranes. These cells were demonstrable both in true germinal centres and, focally and diffusely, in nodular mononuclear infiltrates lacking the histochemical characteristics of germinal centres. The synovial lining cells, unlike mononuclear phagocytes, had no demonstrable receptors for C3 and Fc.