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Analgesic‐induced renal papillary necrosis in the gunn rat: The comparative nephrotoxicity of aspirin and phenacetin
Author(s) -
Axelsen R. A.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711200303
Subject(s) - renal papillary necrosis , phenacetin , nephrotoxicity , aspirin , medicine , nephrectomy , necrosis , analgesic , kidney , pathology , pharmacology
Homozygous Gunn rats, mutant Wistars genetically lacking glucuronyl transferase, develop renal papillary necrosis after single oral doses of aspirin and of phenacetin. The lesion appears significantly more frequently with aspirin than phenacetin, and at lower doses. The model is a convenient one with which to study analgesic nephrotoxicity.