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Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy
Author(s) -
Molland Elizabeth A.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711200106
Subject(s) - aspirin , nephrectomy , calcification , kidney , renal papillary necrosis , medicine , necrosis , hyperplasia , pathology , urology
Aspirin caused epithelial hyperplasia, papillary necrosis with calcification and cortical changes in the rat kidney. After unilateral nephrectomy the lesions appeared more rapidly and were more severe. In the electron microscope the earliest changes were observed in the interstitial cells.