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Cryoimmunoglobulin IgG k with microtubular ultrastructure associated with pyoderma gangrenosum
Author(s) -
White J. C.,
Adam B. A.,
Lau K. S.,
Horne R. W.,
Parkhouse R. M. E.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711200104
Subject(s) - white (mutation) , medicine , university hospital , library science , family medicine , chemistry , biochemistry , computer science , gene
Recurrent gangrenous leg ulcers were associated with a monoclonal IgGk cryoglobulinaemia, though without overt myeloma. Cryoprecipitation of the serum in vitro gave a reversible gel with microtubular structure, built from the monomer and with a high degree of order. The same structure was found distending the superficial vessels of the ulcer biopsy, as well as extravascularly. There was no vasculitis, and luminal obstruction appeared responsible for the ulceration. Microtubular structures occur in nature among diverse proteins and viruses. The protein studied here is similar to a reported instance of myeloma cryo-IgGk.