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An experimental kidney disease in dogs produced by injection of heterologous antisera to dog tubular fraction 3 antigen
Author(s) -
Barabas Arpad Z.,
Lannigan Robert
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711200103
Subject(s) - heterologous , antiserum , antigen , immune system , antibody , glomerulonephritis , kidney , medicine , immunology , pathology , biology , genetics , gene
Glomerular disease characterised by morphological alterations of the glomerular basement membrane and the mesangium was produced in dogs by injections of heterologous anti-dog renal tubular fraction 3 antibody. The renal lesion was characterised by irregular thickening of the glomerular basement membrane, with electron-dense deposits and loose granular material within it.