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Atrophy and apoptosis in the cyclical human endometrium
Author(s) -
Wood D. Hop,
Levison D. A.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711190305
Subject(s) - basophilic , atrophy , endometrium , electron microscope , apoptosis , biology , microbiology and biotechnology , feulgen stain , pathology , endocrinology , medicine , staining , biochemistry , physics , optics
Electron microscopy of human cyclical endometrium indicates that there is considerable loss of gland epithelial cells with formation of apoptotic bodies in the late secretory, premenstrual and menstrual phases, but also to a lesser extent in the proliferative phase. Apoptotic bodies containing nuclear fragments may be recognised on light microscopy as basophilic or Feulgen positive granules. These granules accumulate in greatest numbers towards the end of the cycle and may be used as an additional aid in dating curettings.