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Tubuloreticular structures and antinuclear antibodies in autoimmune and non‐autoimmune diseases
Author(s) -
Helder A. W.,
FeltkampVroom Thea M.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711190108
Subject(s) - anti nuclear antibody , transfusion medicine , medicine , clinical immunology , medical laboratory , autoimmune hemolytic anemia , immunology , antibody , blood transfusion , autoantibody , pathology , allergy
Tissues obtained at random from patients suffering from autoimmune and non-autoimmune diseases were studied for the presence of tubuloreticular structures (TRS). It could be demonstrated that the occurrence of TRS in renal tissue is not a specific characteristic of systemic lupus erythematosus whereas the presence of such structures in skin tissue might be suggestive for this disease. The serum of some of the patients could be studied for the presence of antinuclear antibodies (ANA). A statistically significant correlation was found between TRS and ANA in the group of patients with autoimmune diseases. The possibility is discussed that this correlation might favour the theory that viruses may be involved in the aetiology of autoimmune diseases, particularly of systemic lupus erythematosus.