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Mesangiocapillary glomerulonephritis in lambs. III. Quantitative and qualitative aspects of immunopathology
Author(s) -
Gardiner A. C.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711190104
Subject(s) - immunopathology , glomerulonephritis , immunology , medicine , biology , kidney
Newborn Finnish Landrace lambs subsequently affected with mesangiocapillary glomerulonephritis (MCGN) were deficient in the third component of complement (C'3), serum levels being approximately 5 per cent. of those in unaffected lambs. Hypocomplementaemia persisted until symptoms of renal failure occurred at around 6-8 wk of age. Immunofluorescence examinations of renal cortex with antisera specific for IgG, IgM, IgA, C'3 and fibrin supported previous morphological evidence of a strong similarity between this disease and MCGN in man. Similar examinations of choroid plexus suggested that immune complexes containing IgG, IgM and C'3 were present in the interstitium.