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Renal damage caused by gentamicin: A study of the effects on renal morphology and urinary enzyme excretion
Author(s) -
Wellwood J. M.,
Lovell D.,
Thompson A. E.,
Tighe J. R.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711180307
Subject(s) - gentamicin , excretion , urine , urinary system , kidney , dose , intramuscular injection , endocrinology , aminoglycoside , medicine , necrosis , acute tubular necrosis , chemistry , antibiotics , biochemistry
Gentamicin sulphate was administered to male Wistar rats by intramuscular injection at varying dosage and for varying periods. At high dosage (50-100 mg/kg/day) gentamicin causes tubular necrosis. At dosages equivalent to that given to man (5 mg/kg/day) obvious degenerative changes are produced. Similar changes are seen in human tubular epithelium and urine deposits of patients treated with gentamicin. There is increased excretion of urinary enzymes proportional to the degree of tubular damage. The importance of these changes in man is stressed.