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The fine structure of neoplastic invasion: Invasion of liver, skeletal muscle and lymphatic vessels by the Rd/3 tumour
Author(s) -
Carr I.,
McGinty F.,
Norris P.
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711180205
Subject(s) - lymphatic system , pathology , neoplasm , ultrastructure , biology , cytoplasm , neoplastic cell , cell division , cell , anatomy , microbiology and biotechnology , medicine , genetics
Neoplastic invasion as seen in the rat Rd/3 neoplasm has been studied electron microscopically in three sites: abdominal wall, footpad and liver. This neoplasm invades by peripheral cell division and active cell migration. Neoplastic cells protrude many fine processes and compress host cells. Neoplastic cells invade lymphatic vessels in a way similar to that in which white blood cells penetrate them - by the protrusion of fine cytoplasmic processes and passage, sometimes in clumps through open cell junctions. There is no ultrastructural evidence of secretory phenomena.