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Scanning electron‐microscopic study of the surface characteristics of neoplastic endo‐thelial cells of blood vessels
Author(s) -
Toth Bela,
Malick Linda
Publication year - 1976
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1711180109
Subject(s) - pathology , cytoplasm , transmission electron microscopy , scanning electron microscope , electron microscope , anatomy , endothelial stem cell , chemistry , biology , biophysics , microbiology and biotechnology , materials science , medicine , optics , nanotechnology , physics , composite material , biochemistry , in vitro
The morphological surface characteristics of neoplastic endothelial cells of blood vessels induced by oral administration of 1,2-dimethylhydrazine dihydrochloride in mice were studied by scanning electron microscopy. The interconnecting vascular channels were lined by malignant endothelial cells which formed bridges, cord-like structures and had extended cytoplasmic processes which made the network more intricate. The endothelial cells were often in close approximation to each other and exhibited irregular growth patterns and orientation. The cell surface displayed a rugged, terrace-like microcontour of elevations, depressions, blebs and nodular structures. These findings correlate with the earlier morphological observation obtained by transmission electron microscopy.