Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice | Zendy

Braakhuis Boudewijn JM | Zendy; Leemans C René | Zendy; Brakenhoff Ruud H | Zendy

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Using tissue adjacent to carcinoma as a normal control: an obvious but questionable practice

Author(s) -

Braakhuis Boudewijn JM,

Leemans C René,

Brakenhoff Ruud H

Publication year - 2004

Publication title -

the journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.964

H-Index - 184

eISSN - 1096-9896

pISSN - 0022-3417

DOI - 10.1002/path.1549

Subject(s) - carcinoma , immunohistochemistry , pathology , biology , epithelium , cancer , medicine , genetics

When carcinoma tissue is investigated using biochemical, immunohistochemical, and genetic techniques, adjacent tissue that is macroscopically normal is frequently used as a control, since cancer‐related pheno‐ and geno‐typic alterations are assumed to be absent. However, a field that contains genetically abnormal cells surrounds a significant proportion of carcinomas (for example, over 30% of head and neck cancers). These fields can be large (>7 cm in diameter) and consist of cells that are clonally related to the carcinoma. This indicates that adjacent epithelium must be checked for genetic abnormalities before it is considered normal and used as a control for comparison with carcinoma. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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