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TIMP‐3 and endocrine therapy of breast cancer: an apoptosis connection emerges
Author(s) -
Edwards Dylan R
Publication year - 2004
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1548
Subject(s) - connection (principal bundle) , endocrine system , breast cancer , medicine , cancer , oncology , cancer research , hormone , mathematics , geometry
The tissue inhibitors of metalloproteinases (TIMPs) control the activities of matrix metalloproteinases (MMPs) and as such, they have been recognized as potential suppressors of angiogenesis and tumour invasion and metastasis. However, TIMP‐3 has several unique properties that set it apart from other TIMPs, including its ability to bind to extracellular matrix, inhibit related adamalysin metalloproteinases (ADAMs), and induce apoptosis. New data suggest that high levels of TIMP‐3 mRNAs in human breast tumours are associated with success of adjuvant endocrine therapy, but not chemotherapy. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.