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Integrins in regulation of tissue development and function
Author(s) -
Danen Erik HJ,
Sonnenberg Arnoud
Publication year - 2003
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1416
Subject(s) - integrin , extracellular matrix , microbiology and biotechnology , cell adhesion , cell adhesion molecule , biology , signal transduction , adhesion , extracellular , function (biology) , cell , chemistry , genetics , organic chemistry
An erratum for this article has been published in Journal of Pathology; 201(4): 632–641. Cell adhesion is indispensable for embryonic development and for proper tissue function. In metazoans, integrins are the major adhesion receptors that connect cells to components of the extracellular matrix. Integrins are implicated in assembly of extracellular matrices, cell adhesion and migration on extracellular matrices, and in vertebrates (in which the integrin family has expanded) they can also mediate cell–cell adhesion. Furthermore, integrin‐mediated adhesion can modulate many different signal transduction cascades and support cell survival, proliferation, and influence the expression of differentiation‐related genes. In this review we briefly explain how integrins can affect so many different aspects of cell behavior and discuss evidence for roles of integrins in tissue development, function, and disease. Copyright © 2003 John Wiley & Sons, Ltd.