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Tenascins: regulation and putative functions during pathological stress
Author(s) -
ChiquetEhrismann Ruth,
Chiquet Matthias
Publication year - 2003
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1415
Subject(s) - tenascin , extracellular matrix , tenascin c , pathological , inflammation , microbiology and biotechnology , regeneration (biology) , extracellular , wound healing , function (biology) , cell adhesion , biology , immunology , medicine , pathology , fibronectin , cell , genetics
In this review, we discuss the structure and function of the extracellular matrix protein family of tenascins with emphasis on their involvement in human pathologies. The article is divided into the following sections: Introduction: the tenascin family of extracellular matrix proteins; Structural roles: tenascin‐X deficiency and Ehlers–Danlos syndrome; Tenascins as modulators of cell adhesion, migration, and growth; Role of tenascin‐C in inflammation; Regulation of tenascins by mechanical stress: implications for wound healing and regeneration; Association of tenascin‐C with cancer: antibodies as diagnostic and therapeutic tools; Conclusion and perspectives. Copyright © 2003 John Wiley & Sons, Ltd.