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Epidermal stem cells
Author(s) -
Janes Sam M.,
Lowell Sally,
Hutter Caroline
Publication year - 2002
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1156
Subject(s) - stem cell , epidermis (zoology) , hair follicle , biology , microbiology and biotechnology , adult stem cell , progenitor cell , skin repair , pathology , endothelial stem cell , immunology , medicine , in vitro , wound healing , anatomy , genetics
Abstract The clinical implications of understanding epidermal stem cell biology abound. Thousands of burns victims across the world have benefited from early research into the proliferation of epidermal keratinocytes in vitro . Advances now indicate there are a number of stem cell repositories within the epidermis, two of which, the interfollicular epidermis and the bulge region of the hair follicle, may supply each other when damaged. This review details the progress made in the identification and characterisation of stem cells within the epidermis and discusses the molecules involved in the epidermal stem cell's choice of fate. Finally, the skin, like bone marrow, could be a readily accessible source of stem cells for therapeutic intervention and evidence of skin stem cell plasticity is highlighted.