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Embryonic stem cells
Author(s) -
Bishop Anne E.,
Buttery Lee D. K.,
Polak Julia M.
Publication year - 2002
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1154
Subject(s) - embryonic stem cell , economic shortage , regenerative medicine , induced pluripotent stem cell , stem cell , biology , microbiology and biotechnology , cellular differentiation , genetics , philosophy , linguistics , government (linguistics) , gene
Abstract The capacity of embryonic stem cells for virtually unlimited self‐renewal and differentiation capacity has opened up the prospect of widespread applications in biomedical research and regenerative medicine. For the latter, the cells provide hope that it will be possible to overcome the problems of donor tissue shortage and also, by making the cells immunocompatible with the recipient, implant rejection. Four years after the first derivation of human pluripotent cell lines from pre‐implantation embryos, a great deal has been learnt about their biology and how differentiation can be encouraged towards particular cell lineages. However, considerable research is needed, not least into means to enrich and purify derivative cell lineages, before clinical trials can be considered. Copyright © 2002 John Wiley & Sons, Ltd.