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Markers of senescence?
Author(s) -
Coates Philip J.
Publication year - 2002
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/path.1073
Subject(s) - senescence , biology , cellular senescence , endogeny , enzyme , identification (biology) , cell , cell type , microbiology and biotechnology , biochemistry , phenotype , gene , botany
Abstract The specific identification of cellular senescence in clinical material has important implications for determining the role of senescence in age‐related pathologies and in neoplasia in certain tumours. One suggested marker of senescence is the histochemical identification of a specific β‐galactosidase enzyme operative at pH 6.0. However, recent data indicate that this enzyme may not be specific for senescence in all tissues and probably represents the expression of endogenous lysosomal acid β‐galactosidase, which is expressed by a variety of differentiated cell types. Copyright © 2002 John Wiley & Sons, Ltd.